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Non-Hogkin’s lymphoma can occur in both children and adults. The disease develops when cancer cells form in the lymph system. Lymph tissue is found throughout the body, can begin in almost any part of the body and may spread to the liver and other organs or tissues. Potential signs of non-Hodgkin’s lymphoma include fever, sweating, fatigue and weight loss. Other signs could include painless swelling in the lymph nodes in the neck, underarm, groin or stomach.
New types of treatment are being tested to fight non-Hodgkin’s lymphoma and keep it from recurring. Clinical trials are testing the use of vaccine therapy to cause the immune system to attack the tumor and destroy it. Also, clinical trials are used to research the effects of high-dose chemotherapy with stem cell transplant, where cells are removed before chemotherapy, preserved and then returned to the patient after cancer treatment to help the body restore blood cells.
The risk of developing adult non-Hodgkin’s lymphoma may be affected by age, gender and a weakened immune system. Older, white males are more susceptible to developing adult non-Hodgkin's lymphoma. If a person has an inherited immune disorder, an autoimmune disease, HIV/AIDS, Human T-lymphotropic virus type I or Epstein-Barr virus or a history of Helicobacter pylori infection, they are at a higher risk of diagnosis of adult non-Hodgkin’s lymphoma. Other risk factors that affect a patient’s chance of developing the disease include taking immunosuppressant drugs after an organ transplant, exposure to certain pesticides, consuming a diet high in meats and fats and past treatment for non-Hodgkin’s lymphoma. Recovery and treatment options depend upon the stage and type of non-Hodgkin’s lymphoma, as well as the level of lactate dehydrogenase (LDH) in the blood.
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